ea0015p257 | Pituitary | SFEBES2008
Melrose Zoe
, Eltobgi Adim
, Abbott Lee
, Munir Alia
, Newell-Price John
Introduction: Although current medical therapies for acromegaly are highly effective, 30% of patients are left with inadequately controlled growth hormone (GH) levels. To investigate a novel therapeutic strategy we have used RNA interference (RNAi) to target GH coding and promoter sequences in vitro and assessed the effect on gene expression and DNA methylation.Method: A careful bioinformatics approach revealed only one area in the coding sequence...